Immune Derangement in Patients with Malignant Melanoma
β Scribed by M. G. LEWIS; T. M. PHILLIPS; P. B. NOBLE; D. P. HARTMANN
- Book ID
- 109381045
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 487 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0303-6987
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## Abstract The effects of active specific immunization with nonirradiated autologous and irradiated cultured allogeneic melanoma tumor cells (TC) on cellβassociated immunity was studied in 11 patients with widespread malignant melanoma receiving chemoimmunotherapy. Immunization with 1 Γ 10^6^β8 Γ
Lymphocyte blastogenesis (LB) with PHA, CON-A, PWM, V,, (homologous tumor extract) plus T/B ratio for pre-IT, post-IT (2 months), and 3, 6, 9, 12, 18, and 24 months prior to each V,, booster are reported. Pre-IT and post-IT LB-PHA were similar for Stage I (ST I) or Stage I1 (ST 11) breast cancer (BC