Immune Deficiency Disorders with Autoimmunity and Abnormalities in Immune Regulation—Monogenic Autoimmune Diseases
✍ Scribed by Heather K. Lehman; Mark Ballow
- Book ID
- 107568337
- Publisher
- Humana Press Inc
- Year
- 2007
- Tongue
- English
- Weight
- 97 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1080-0549
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Twenty-five families including 34 individuals with common variable immune deficiency (CVID), with at least one affected female in each family, were studied. The distribution of cases within families was compatible with autosomal recessive inheritance, making it plausible to test hypotheses about the
ollowing antigen exposure, mature lymphocytes require intense, prolonged and repeated proliferation to establish a rapid immune response and generate immunological memory. Proliferation also precedes induction of tolerance to soluble antigens. In addition, immune cells in bone marrow or thymus under