β Scribed by J. L. Ninnemann (auth.), Priv.-Doz. Dr. med. Eugen Faist, John L. Ninnemann Ph. D., Douglas R. Green Ph. D. (eds.)
No coin nor oath required. For personal study only.
Sepsis and infection are the major enemies of the intensive care patient in whom immunological defenses are severely impaired. This major problem is thefocus of attention in this book, based on the presentation of the First International Congress on the Immune Consequences of Trauma, Shock, and Sepsis, which is one of the first attempts to exchange ideas on the state-of-the-art in this area of immunology. Both basic and clinical research, including new centres of attention, are described. The growing role of immunology in medicine opens new avenues to the under- standing of trauma and sepsis and will allow the design of novel therapeutic approaches.
Front Matter....Pages I-XX
Front Matter....Pages 1-1
The Immune Consequences of Trauma: An Overview....Pages 3-8
Trauma: Immune Deficiency, Immune Suppression, or Just Immune Cell Redistribution?....Pages 9-15
Neuroendocrine Response to Severe Trauma and Sepsis....Pages 17-32
Front Matter....Pages 33-33
Regulation of Hematopoiesis by Growth Factors: Proliferation of the Murine Macrophage as a Model for Stimulatory and Inhibitory Effects....Pages 35-44
The Activation of Immune Effector Cells: Role of Helper and Inflammatory CD4 T Cell Subsets....Pages 45-54
The Role of Inhibitory Cells in Burn Trauma-Associated Immunodeficiency....Pages 55-62
Macrophage β T-Cell Interactions in Surgical Sepsis....Pages 63-68
The Relationship Between T Cells and Interleukin 1....Pages 69-77
Trauma-Induced Alterations of the Lymphokine Cascade....Pages 79-94
Alterations of Monocyte Function Following Major Injury....Pages 95-108
Possible Use of the Monocyte/Macrophage Activation Marker Neopterin for Clinical Monitoring of Sepsis-Related Multiorgan Failure....Pages 109-114
Expression of Functional Interleukin 2 Receptors in Burn Patients May Be Regulated by Interleukin 3....Pages 115-118
Role of Monocyte HLA-DR Expression Following Trauma in Predicting Clinical Outcome....Pages 119-122
Early Alterations in HLA Class II Expression and Response to Tetanus Toxoid by Peripheral Blood Monocytes from Patients with Injury from Burns or Trauma....Pages 123-129
Lymphocyte Surface Antigen Expression Following Lectin Stimulation: An Index of Early T-Cell Dysfunction After Controlled Murine Injury....Pages 131-136
Role of T-Cell Lymphocyte Populations and Their Products as Mediators of Immune Depression in Thermal Burns....Pages 137-141
The Influence of Mechanical Trauma on the B-Cell System: Phenotypes, Terminal B-Cell Maturation, Immunoglobulin Synthesis and Influence of Lymphokines....Pages 143-156
Activation of B Cells Spontaneously Secreting Ig After Surgery....Pages 157-161
Front Matter....Pages 163-163
Pathobiochemical Mechanisms in Inflammation....Pages 165-172
Cytokines and Oxygen Radical Responses....Pages 173-178
Front Matter....Pages 163-163
Structure and Properties of a Novel Neutrophil-Activating Factor (NAF) Produced by Human Monocytes....Pages 179-183
The Effect of Injury on Murine Neutrophil Oxidative Metabolism....Pages 185-189
Opsonophagocytosis in Patients Undergoing Abdominal Surgery....Pages 191-194
Effects of Pyocyanine, Liberated by Pseudomonas aeruginosa , on the Oxidative Burst of Phagocytes....Pages 195-199
Polymorphonuclear Leukocyte Function Following Burn and Mechanical Injury: Regulation and Kinetics....Pages 201-213
The Role of Complement in Injury....Pages 215-218
Control of Acute-Phase Protein Production....Pages 219-228
Elastase from Polymorphonuclear Leukocytes, Complement, and C-Reactive Protein in Multiple Trauma Patients....Pages 229-234
Flow Cytometric Analysis of Phagocytosis, Respiratory Burst, Intracellular pH, and Cytosolic Free Calcium of Granulocytes of Post-traumatic and Septic Patients....Pages 235-240
Cellular and Humoral Reactions of the Nonspecific Immune System of Polytraumatized Patients with and without the Adult Respiratory Distress Syndrome....Pages 241-246
Granulocyte Adherence in Patients Undergoing Cardiac Surgery Under Cardiopulmonary Bypass....Pages 247-249
Studies on the Release of Lipoxygenase Products from Granulocytes of Severely Burned Patients....Pages 251-257
Front Matter....Pages 259-259
Immune Modulation by Microorganisms....Pages 261-269
Endotoxin-Induced Impairment of Host Defenses....Pages 271-278
Prostaglandins and Leukotrienes in Monocyte/T Cell Function in Stress and Trauma....Pages 279-284
Serum Mediators and the Generation of Immune Suppression....Pages 285-291
Trauma Peptide T-Cell Suppression: Mechanisms of Action....Pages 293-296
Role of Platelet-Activating Factor and Structurally Related Alkyl Phospholipids in Immune and Cytotoxic Processes....Pages 297-305
Regulatory Role of Platelet-Activating Factor on Cytokine Production....Pages 307-310
Potential Role for Platelet-Activating Factor and Tumor Necrosis Factor in the Immune Impairments in Shock and Trauma....Pages 311-321
Front Matter....Pages 259-259
Suppression of Endotoxin-Induced Monokine Release by Human Serum Fractions....Pages 323-326
Role of Corticosteroids in the Pathogenesis of Post-traumatic Thymic Involution....Pages 327-332
Front Matter....Pages 333-333
Immunology of Skin....Pages 335-337
Immune Regulation of Wound Healing....Pages 339-349
Aspects of Immunological Control of Compensatory Organ Growth....Pages 351-354
Front Matter....Pages 355-355
Relationship Between Immune Function and Posttrauma Morbidity and Mortality....Pages 357-362
Immunological Alterations Following Simple Hemorrhage....Pages 363-373
Blood Transfusions: The Immunologic Sequelae....Pages 375-382
Nutrition and Resistance to Sepsis....Pages 383-388
The Gut-Origin Septic States....Pages 389-402
The Influence of Anesthetic Agents on the Immune Response: A Crucial Factor in Immune Suppression?....Pages 403-410
Comparison of the Effects of General Endotracheal and Epidural Anesthesia on the Immune Functions....Pages 411-417
Effect of Splenectomy Upon the Antibody Response to Pneumococcal Immunization....Pages 419-421
Surgical Aspects of AIDS....Pages 423-425
Front Matter....Pages 427-427
Immunomodulation and the Surgeon....Pages 429-439
Immune Consequences of the Acute Stress Response and Sepsis....Pages 441-449
Immunomodulation in Animal Models of Injury....Pages 451-458
Use of Plasma Exchange in Thermally Injured Patients....Pages 459-474
In Vivo Infusion of a Single Dose of Endotoxin in Healthy Humans Causes In Vitro Alterations of Both T-Cell and Adherent Cell Functions....Pages 475-483
Treatment of Burn Patients with Polymyxin B: Effects on Lymphokine Regulation....Pages 485-493
Front Matter....Pages 427-427
Mechanisms of Neutralization of Endotoxin by Monoclonal IgG Antibodies to Lipopolysaccharide....Pages 495-500
Investigations to Demonstrate the Antibacterial and Antitoxic Efficacy of an IgM-Enriched Intravenous Immunoglobulin Preparation....Pages 501-507
Therapy of Secondary T-Cell Immunodeficiencies with Biological Substances and Drugs....Pages 509-517
Immunomodulation as a Potential Therapeutic Approach in Immunodeficiencies....Pages 519-529
Perioperative Immunomodulation in Patients with Major Surgical Trauma....Pages 531-549
Effect of Therapeutic Gamma-Interferon Administration on Wound Infection After Resuscitated Hemorrhagic Shock....Pages 551-555
Back Matter....Pages 557-566
Allergology; Immunology; Traumatic Surgery; Intensive / Critical Care Medicine; Anesthesiology
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