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Immobilized α-melanocyte stimulating hormone 10–13 (GKPV) inhibits tumor necrosis factor-α stimulated NF-κB activity

✍ Scribed by J.M. Kelly; A.J.G. Moir; K. Carlson; Y. Yang; S. MacNeil; J.W. Haycock


Book ID
116830814
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
265 KB
Volume
27
Category
Article
ISSN
0196-9781

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The neuropeptide ␣-melanocyte-stimulating hormone (␣-MSH) modulates inflammation by inhibiting production of proinflammatory cytokines. Using a plasmid vector encoding ␣-MSH, we examined whether autocrine ␣-MSH inhibits activation of the nuclear transcription factor NF-B, a factor that is essential