Immobilized hemoglobin in the purification of hemoglobin-based oxygen carriers
โ Scribed by Emilia Chiancone; Clara Fronticelli; Maurizio Gattoni; Barbara K. Urbaitis; Enrico Bucci
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 905 KB
- Volume
- 604
- Category
- Article
- ISSN
- 1873-3778
No coin nor oath required. For personal study only.
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## Abstract Unmodified cellโfree hemoglobin (Hb) is structurally unstable when transfused into the blood stream (Valeri et al., Artif Cells Blood Substit Immobil Biotechnol. 2000;28:451โ475; Chan et al., Toxicol Pathol. 2000;28:635โ642; Eike, Dissertation, 2005; Eike and Palmer, Biotechnol Prog. 20
## Abstract A mathematical model was developed to study O~2~ transport in a convection enhanced hepatic hollow fiber (HF) bioreactor, with hemoglobinโbased O~2~ carriers (HBOCs) present in the flowing cell culture media stream of the HF lumen. In this study, four HBOCs were evaluated: PEGโconjugate