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Immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus

โœ Scribed by Heather B. Patisaul; Eleni A. Aultman; Isadora F. Bielsky; Larry J. Young; Mark E. Wilson

Book ID
113999523
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
436 KB
Volume
978
Category
Article
ISSN
0006-8993

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The effects of single doses of tamoxifen (TAM; 0.5-5 mg/kg, i.v.) and chronic pretreatment with TAM (0.1-5.0 mg/kg/day, i.p. for 7 consecutive days) on letrozole (0.5 mg/kg, i.v.) pharmacokinetics were evaluated in female Sprague-Dawley rats. The plasma concentration-time profiles of letrozole (0.1-