Immediate and delayed effects of vincristine administered during early postimplantation stages of murine embryogenesis

✍ Scribed by Wan, Yu-Jui ;Wu, Tsung-Chieh ;Damjanov, Ivan

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 552 KB
• Volume: 227
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1402270108

✦ Synopsis

Vincristine was given to pregnant mice on day 7% of pregnancy and the teratogenic effects of this treatment were assessed 2 and 3 days thereafter. Most of the embryos in litters removed on day 9% of pregnancy (2 days after treatment) were morphologically normal, whereas on day 10% most embryos were either developmentally retarded by the treatment or malformed. The morphologically "normal" embryos removed on day 9% of pregnancy were cultured in vitro for 24 h. During this procedure more than 50% of them showed growth retardation or abnormal development. These data indicate that exposure of early postimplantation embryos to vincristine has an immediate teratogenic and embryocidal action, and also a delayed effect which becomes apparent only several days after exposure and following an ostensibly "normal" period of embryonic development.