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Imipramine but not 5-HT1A receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT1A and 5-HT4 receptors

✍ Scribed by Agnieszka Zahorodna; Krzysztof Tokarski; Maria Bijak

Book ID
114014703
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
234 KB
Volume
443
Category
Article
ISSN
0014-2999

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Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT 1A -receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these