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Iminoheptitols as glycosidase inhibitors: Synthesis of, and mannosidase and fucosidase inhibition by, α—homomannojirimycin and 6-epi-homomannojirimycin

✍ Scribed by Ian Bruce; George W.J. Fleet; Isabelle Cenci di Bello; Bryan Winchester

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 280 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)93952-8

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✦ Synopsis

C-2 and C-6 of a heptonolactone are joined together by nitrogen to afford a-homomannojirimycin (HMJ) and &epi-a-homomannojirimycin:

the inhibition of some n-mannosidases and a-fucosidases by these iminoheptitols is reported.

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