Imines in Stille-Type Cross-Coupling Reactions: A Multicomponent Synthesis of α-Substituted Amides

✍ Scribed by Jason L. Davis; Rajiv Dhawan; Bruce A. Arndtsen

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 146 KB
• Volume: 116
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200352123

✦ Synopsis

Palladium-catalyzed cross-coupling processes such as the Stille reaction have emerged as some of the more important methods for the construction of carbon-carbon bonds. [1][2][3] A useful feature of the Stille coupling is its use of nonpolar organostannanes, rather than nucleophilic agents, in reactions with organic halides. Organotin reagents are generally airand moisture-stable, and they can be prepared with a diverse range of transferrable substituents, many of which are less readily formed, or unavailable, within nucleophilic reagents [*] J.