Imbalance of sex chromosomes, with gain of early-replicating X, in human solid tumors

Molecular studies of the sex chromosomes

Molecular studies of the sex chromosomes in human testicular cancer: Pronounced changes in X and Y chromosome dosage in some tumors

✍ Dr. Päivi Peltomäki; Antero Halme; Albert de la Chapelle 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 560 KB

Nine males with testicular germ cell tumors were studied by Southern blotting using probes recognizing different regions of the X and Y chromosomes. In the tumors of three patients, an imbalance was noted with a relative deficiency of DNA of Y-chromosomal and a concurrent excess of that of X-chromos