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Imbalance of hepatic metalloproteinases and their major tissue inhibitor in mice with homozygous disruption of the Mdr2 P-glycoprotein gene

✍ Scribed by Lammert, Frank; Roeb, Elke; Dietrich, Christoph; Matern, Siegfried


Book ID
122972369
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
186 KB
Volume
118
Category
Article
ISSN
0016-5085

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In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta