Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance
✍ Scribed by Hochhaus, A; La Rosée, P
- Book ID
- 110055950
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 187 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0887-6924
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## Abstract ## BACKGROUND Myelofibrosis is associated historically with a poor prognosis in patients with chronic myelogenous leukemia (CML). Its significance in the recent era of effective therapy with imatinib mesylate is unknown. ## METHODS The current study evaluated the significance of the
## Abstract ## BACKGROUND Imatinib mesylate administration has become standard treatment for patients with chronic myelogenous leukemia (CML). Although the safety profile of imatinib is favorable, Grade ≥ 3 neutropenia (according to the National Cancer Institute Common Toxicity Criteria) occurs in
## Abstract ## BACKGROUND Reticulin‐stained bone marrow fibrosis is associated with a poor prognosis in patients with chronic myelogenous leukemia (CML). Resolution of fibrosis with therapy may improve patient outcome. ## METHODS The effect of imatinib therapy on bone marrow fibrosis was evaluat