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Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor

✍ Scribed by H. Kameda; H. Ishigami; M. Suzuki; T. Abe; T. Takeuchi

Book ID: 110090480
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 190 KB
Volume: 144
Category: Article
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2006.03067.x

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## Abstract Most gastrointestinal stromal tumors (GISTs) have gain‐of‐function mutations of the c‐__kit__ gene. Previously, we found 2 types of gain‐of‐function mutation of the __PDGFRA__ gene, Val^561^ to Asp and Asp^842^ to Val, in about half of GISTs without c‐__kit__ gene mutations. Although th