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Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells

โœ Scribed by Mihnea V. Chiorean; Maria Eugenia Guicciardi; Jung-Hwan Yoon; Steven F. Bronk; Scott H. Kaufmanns; Gregory J. Gores

Book ID
111237294
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
231 KB
Volume
24
Category
Article
ISSN
0106-9543

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## Abstract We compare the effects of Imatinib mesylate (Glivecยฎ) on chronic myeloid leukemia derived cell lines K562 and JURLโ€MK1. In both cell lines, the cell cycle arrests in G~1~/G~0~ phase within 24 h after the addition of 1 ฮผM Imatinib. This is followed by a decrease of Kiโ€67 expression and t