## Abstract ## BACKGROUND Reticulinβstained bone marrow fibrosis is associated with a poor prognosis in patients with chronic myelogenous leukemia (CML). Resolution of fibrosis with therapy may improve patient outcome. ## METHODS The effect of imatinib therapy on bone marrow fibrosis was evaluat
Imatinib mesylate causes growth deceleration in pediatric patients with chronic myelogenous leukemia
β Scribed by Maynika V. Rastogi; Linda Stork; Brian Druker; Carolyn Blasdel; Thuan Nguyen; Bruce A. Boston
- Book ID
- 112168124
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 462 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1545-5009
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π SIMILAR VOLUMES
A physician or a group of physicians considers presentation and evolution of a real clinical case, reacting to clinical information and data (boldface type). This is followed by a discussion/commentary.
## Abstract ## BACKGROUND. The prognosis of patients with chronic myelogenous leukemia (CML) after failure of imatinib mesylate therapy is not well documented. ## METHODS. The outcome of 420 patients with CML postβimatinib failure (resistanceβrecurrence in 374; toxicities in 46) were reviewed in
## Abstract ## BACKGROUND Imatinib mesylate induces high rates of hematologic and cytogenetic response in patients with chronic myelogenous leukemia (CML). During therapy with imatinib, up to 45% of patients with CML reportedly experience myelosuppression β₯ Grade 3, requiring interruption of thera