✦ LIBER ✦

Imatinib mesylate as a cause of acute liver failure

✍ Scribed by Timothy J.S. Cross; Catherine Bagot; Bernard Portmann; Julia Wendon; D. Gillett

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 151 KB
Volume: 81
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.20486

No coin nor oath required. For personal study only.

✦ Synopsis

A 46-year-old patient diagnosed with chronic myeloid leukemia in whom cytogenetic and molecular remission had never been achieved was commenced on Imatinib Mesylate (Gleevecâ, Novartis Pharmaceuticals Corp., East Hanover, NJ). After 18 months of treatment, she developed abnormal liver function tests and subsequently acute liver failure, requiring transfer to the regional liver unit. The patient proceeded to liver transplantation but later died. The explanted liver had histological features of severe hepatic necrosis. This is the first case described of fatal hepatic necrosis in a patient who has have been on long-term imatinib therapy. This may have implications for long-term use of the drug and emphasizes the need for regular monitoring of liver function. Am.

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