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Imatinib inhibits in vitro proliferation of cells derived from a pleural solitary fibrous tumor expressing platelet-derived growth factor receptor-beta

✍ Scribed by Prunotto, Marco; Bosco, Martino; Daniele, Lorenzo; Macri’, Luigia; Bonello, Lisa; Schirosi, Laura; Rossi, Giulio; Filosso, Pierluigi; Mussa, Baudolino; Sapino, Anna

Book ID
119320048
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
663 KB
Volume
64
Category
Article
ISSN
0169-5002

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## Abstract Most gastrointestinal stromal tumors (GISTs) have gain‐of‐function mutations of the c‐__kit__ gene. Previously, we found 2 types of gain‐of‐function mutation of the __PDGFRA__ gene, Val^561^ to Asp and Asp^842^ to Val, in about half of GISTs without c‐__kit__ gene mutations. Although th