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Imaging trauma in vivo: GABAA benzodiazepine receptor binding

✍ Scribed by Geuze, E; van Berckel, B N M; Lammertsma, A A; Boellaard, R; de Kloet, C S; Vermetten, E; Westenberg, H G M

Book ID
110060391
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
67 KB
Volume
13
Category
Article
ISSN
1359-4184

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Acute barbiturate administration increas
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Barbiturates have been reported to augment benzodiazepine receptor affinity in vitro, but their effects in vivo are uncertain. We determined benzodiazepine receptor binding in vivo by specific uptake of [3H]Ro15-1788 after barbiturate administration. Pentobarbital (30 mg/kg) increased receptor bindi