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Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors

โœ Scribed by Smith-Jones, Peter M; Solit, David B; Akhurst, Timothy; Afroze, Farzana; Rosen, Neal; Larson, Steven M


Book ID
109911196
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
408 KB
Volume
22
Category
Article
ISSN
1087-0156

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## Abstract ## Objective The NFโ€ฮบB signaling pathway promotes the immune response in rheumatoid arthritis (RA) and in rodent models of RA. NFโ€ฮบB activity is regulated by the IKKโ€2 kinase during inflammatory responses. To elucidate how IKKโ€2 inhibition suppresses disease development, we used a comb