Imaging of tumour neovasculature by targeting the TGF-β binding receptor endoglin
✍ Scribed by S Bredow; M Lewin; B Hofmann; E Marecos; R Weissleder
- Book ID
- 117666979
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 513 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0959-8049
No coin nor oath required. For personal study only.
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## Abstract Endoglin (CD105) is a cell membrane glycoprotein over‐expressed on highly proliferating endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within benign and malignant tissues. CD105 binds several factors of the Transforming Growth Factor (TGF)‐β superfa
The growth factors PDGF-AA and PDGF-BB have previously been shown to be potent mitogens for human periodontal ligament (hPDL) cells in vitro. Additionally, the mitogenic response to PDGF-AA has been shown to be specifically inhibited by TGF-P. The purpose of the present investigation was to examine