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Imaging of Germinal Center Selection Events During Affinity Maturation

✍ Scribed by Allen, C. D. C.; Okada, T.; Tang, H. L.; Cyster, J. G.

Book ID
126311694
Publisher
American Association for the Advancement of Science
Year
2007
Tongue
English
Weight
661 KB
Volume
315
Category
Article
ISSN
0036-8075

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✍ Mihaela Oprea; Erik van Nimwegen; Alan S. Perelson πŸ“‚ Article πŸ“… 2000 πŸ› Springer 🌐 English βš– 320 KB

During an immune response, the affinity of antibodies that react with the antigen that triggered the response increases with time, a phenomenon known as affinity maturation. The molecular basis of affinity maturation has been partially elucidated. It involves the somatic mutation of immunoglobulin V