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Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

✍ Scribed by Karsten Henkel; Jochen Karitzky; Michaela Schmid; Irina Mader; Gerhard Glatting; Jürgen W. Unger; Bernd Neumaier; Albert C. Ludolph; Sven N. Reske; G. Bernhard Landwehrmeyer

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
229 KB
Volume
19
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Positron emission tomography (PET) using [^11^C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left‐sided symptoms was studied using fluorodeoxyglucose (FDG) and [^11^C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [^11^C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD. © 2004 Movement Disorder Society

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