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Imaging microglial activation in a mouse model of Alzheimer's disease using PET/MRI and ex vivo autoradiography

โœ Scribed by James, Michelle; Nguyen, Thuy-Vi; Belichenko, Nadia; Andrews, Lauren; Liu, Hongguang; Bodapati, Deepika; Shen, Bin; Cheng, Zhen; Gambhir, Sanjiv; Longo, Frank M.; Chin, Frederick

Book ID
122667980
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
676 KB
Volume
9
Category
Article
ISSN
1552-5260

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Passive staining: A novel ex vivo MRI pr
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โœ Marc Dhenain; Benoรฎt Delatour; Christine Walczak; Andreas Volk ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 470 KB

## Abstract Amyloid plaques are one of the hallmarks of Alzheimer's disease (AD). This study evaluated a novel ฮผMRI strategy based on โ€œpassive stainingโ€ of brain samples by gadoteric acid. The protocol was tested at 4.7T on control animals and APP/PS1 mice modeling AD lesions. T~1~ was strongly dec