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Imaging cAMP-specific phosphodiesterase-4 in human brain withR-[11C]rolipram and positron emission tomography

✍ Scribed by DaSilva, Jean; Lourenco, Celia; Meyer, Jeffrey; Hussey, Douglas; Potter, William; Houle, Sylvain


Book ID
113026072
Publisher
Springer
Year
2002
Tongue
English
Weight
200 KB
Volume
29
Category
Article
ISSN
0340-6997

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Imaging of cAMP-specific phosphodiestera
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The phosphodiesterase type IV (PDEIV) family of enzymes contributes to the metabolism of cAMP formed by the stimulation of beta-adrenergic, A2-adenosine, and H2-histamine receptors in the brain. Disturbances in cAMP-mediated signaling have been implicated in several neuropsychiatric disorders, and t