Imaging assessment of the responses of osteosarcoma patients to preoperative chemotherapy : Angiography compared with thallium-201 scintigraphy

✍ Scribed by Toshiyuki Kunisada; Toshifumi Ozaki; Akira Kawai; Shinsuke Sugihara; Kohji Taguchi; Hajime Inoue

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 287 KB
• Volume: 86
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19990915)86:6<949::aid-cncr9>3.0.co;2-h

✦ Synopsis

BACKGROUND.

Assessment of the responses of osteosarcoma patients to preoperative chemotherapy is of clinical importance. The purpose of this study was to estimate the accuracy of angiography and thallium-201 scintigraphy, compared with histology, in assessing the responses of patients with osteosarcoma to preoperative chemotherapy.

METHODS.

Nineteen patients with osteosarcoma who were diagnosed between 1992 and 1997 were studied. The findings of angiography and thallium-201 scintigraphy before and after preoperative chemotherapy were compared with the percentage of necrosis of tumor cells and the response grade as determined histologically. Quantitative analysis of the isotopic uptake by thallium-201 scintigraphy before and after chemotherapy, defined as the alteration ratio, was correlated with the percentage of tumor necrosis.