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Imaging [18F]FAU [1-(2′-deoxy-2′-fluoro-beta-D-arabinofuranosyl) uracil] in dogs

✍ Scribed by Haihao Sun; Jerry M Collins; Thomas J Mangner; Otto Muzik; Anthony F Shields


Book ID
117687891
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
140 KB
Volume
30
Category
Article
ISSN
0969-8051

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Synthesis of [2-14C]-1-(2-deoxy-2-fluoro
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The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (

Synthesis of 1-(2-deoxy-2-fluoro-β-D-ara
✍ J. E. Swigor; K. A. Pittman 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 232 KB 👁 1 views

The synthesis of t h e title canpound (7) is described. [2-14C] cytosine (I) is treated with an aqueous mixture of sodium bisulfite and sodium sulfate at 8OoC for 30 rnin. The resulting solid is then treated with aqueous sodiun hydroxide and passed through a cation exchange colunn, producing [ Z-14C