✦ LIBER ✦

Images-based suppression of unwanted global signals in resting-state functional connectivity studies

✍ Scribed by Federico Giove; Tommaso Gili; Vittorio Iacovella; Emiliano Macaluso; Bruno Maraviglia

Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 624 KB
Volume: 27
Category: Article
ISSN: 0730-725X
DOI: 10.1016/j.mri.2009.06.004

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✦ Synopsis

Correlated fluctuations of low-frequency fMRI signal have been suggested to reflect functional connectivity among the involved regions. However, large-scale correlations are especially prone to spurious global modulations induced by coherent physiological noise. Cardiac and respiratory rhythms are the most offending component, and a tailored preprocessing is needed in order to reduce their impact. Several approaches have been proposed in the literature, generally based on the use of physiological recordings acquired during the functional scans, or on the extraction of the relevant information directly from the images. In this paper, the performances of the denoising approach based on general linear fitting of global signals of noninterest extracted from the functional scans were assessed. Results suggested that this approach is sufficiently accurate for the preprocessing of functional connectivity data.

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