Image Printing on the Surface of Anti-Biofouling Zwitterionic Polymer Brushes by Ion Beam Irradiation
✍ Scribed by Hiromi Kitano; Hisatomo Suzuki; Takuya Kondo; Kenta Sasaki; Shintaroh Iwanaga; Makoto Nakamura; Kohji Ohno; Yoshiyuki Saruwatari
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 430 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
A CMB monomer was polymerized on a glass plate with a surface‐confined ATRP initiator containing a 2‐bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non‐specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furthermore, the PCMB brush was ablated and a hollow space with a designed shape could be made to which HEK293 cells (from human embryonic kidney) and Hep G2 (from human hepatoma) cells non‐specifically adhered, while no adhesion of these cells to the non‐treated area on the brush was observed. The present results clearly indicate the usefulness of ion beam‐printed patterns of anti‐biofouling zwitterionic polymer brushes in the biomedical field. magnified image