Image cytometry of early nuclear events during apoptosis induced by camptothecin in HL-60 leukemic cells

There is substantial nuclear and cellula

There is substantial nuclear and cellular disintegration before detectable phosphatidylserine exposure during the camptothecin-induced apoptosis of HL-60 cells

✍ Malcolm A. King; Monica A. Radicchi-Mastroianni; John V. Wells 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 527 KB

Background: An early sign of apoptosis in many cells is the appearance of phosphatidylserine (PS) on the outside of the plasma membrane, whilst the cells still retain the ability to exclude DNA-binding molecules such as propidium iodide and 7-aminoactinomycin D (7-AAD). The protein annexin V binds p