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Ill-fated amyloid-β vaccine

✍ Scribed by Mark A. Smith; Craig S. Atwood; James A. Joseph; George Perry

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
28 KB
Volume
69
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

The premature suspension of the amyloid-␤ vaccine for the treatment of Alzheimer disease (AD), while disappointing, is not surprising. Amyloid-␤ serves a key role in redox homeostasis (Nunomura et al., 2001) and its removal, by vaccination (or others) strategies, would be predicted to increase oxidative stress and consequently led to an inflammatory cascade (Perry et al., 2002). Such inflammation of the brain lead to the halting of the vaccine trial and should also cause all in the field to pause for thought before pursing other amyloid-␤-based therapeutics which will also likely exacerbate the disease process (Smith et al., 2000;Joseph et al., 2001).

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