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IL9maps to mouse chromosome 13 and human chromosome 5

✍ Scribed by Beverly A. Mock; Marianne Krall; Christine A. Kozak; Muriel N. Nesbitt; O. Wesley McBride; Jean-Christophe Renauld; Jacques Snick

Publisher: Springer-Verlag
Year: 1990
Tongue: English
Weight: 514 KB
Volume: 31
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00204898

No coin nor oath required. For personal study only.

✦ Synopsis

Mouse and human cDNA clones encoding the T-cell and mast cell growth factor P40, now designated IL-9, were used to identify DNA restriction fragment length polymorphisms (RFLPs) in sets of somatic cell hybrids and between inbred strains of mice and interspecific backcross progeny. Segregation of mouse and human chromosomes among somatic cell hybrids indicated a location on mouse chromosome 13 and human chromosome 5. RFLPs were identified among inbred strains of mice. Analysis of chromosome 13 alleles for Tcrg, Dhfr, and Il-9 in an interspecific cross between Mus musculus and NFS/N or C58/J mice indicates that IL9 is distal to Tcrg and proximal to Dhfr.

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