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IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: New tools for analysis of IL-7 expressing cells

✍ Scribed by John F. Repass; Micheline N. Laurent; Carla Carter; Boris Reizis; Mark T. Bedford; Kim Cardenas; Priyanka Narang; Mark Coles; Ellen R. Richie

Book ID: 102156226
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 390 KB
Volume: 47
Category: Article
ISSN: 1526-954X
DOI: 10.1002/dvg.20497

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Cover Picture: The cover image features

Cover Picture: The cover image features a frozen section from an embryonic day 16 mouse spleen stained by immunofluorescence to demonstrate the presence and location of lymphoid tissue inducer (LTi) cells. Withers et al. (pp. 3240–3245) show that these cells form the focus of lymphocyte accumulation in the developing mouse spleen. Red staining for CD45 marks haemopoietic cells, green shows IL-7Rα expression, and CD4 expression is in blue. LTi cells that express all markers (in white) cluster around blood vessels in the embryonic spleen where signalling to stromal cells initiates lymphocyte recruitment. – Eur. J. Immunol. 11/2007

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