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IL28Ralpha Deficiency Enforces T Cell-Dependent Experimental Colitis via Suppression of Regulatory T-Cells

✍ Scribed by Heike Dornhoff; Sean Doyle; Markus F. Neurath; Jürgen Siebler

Book ID
119432455
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
141 KB
Volume
140
Category
Article
ISSN
0016-5085

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## Abstract Human autoimmune diseases are often characterized by a relative deficiency in CD4^+^CD25^+^ regulatory T cells (Treg). We therefore hypothesized that expansion of Treg can ameliorate autoimmune pathology. We tested this hypothesis in an experimental model for autoimmune myasthenia gravi