Insulin resistance affects sustained virological response (SVR) in chronic hepatitis C. To know whether adding metformin to standard antiviral treatment improves SVR, we conducted a prospective, multicentered, randomized, double-blinded, placebo-controlled trial in 19 Spanish hospitals, including 12
IL28B polymorphisms determine early viral kinetics and treatment outcome in patients receiving peginterferon/ribavirin for chronic hepatitis C genotype 1
✍ Scribed by M. Lindh; M. Lagging; B. Arnholm; A. Eilard; S. Nilsson; G. Norkrans; J. Söderholm; T. Wahlberg; R. Wejstål; J. Westin; K. Hellstrand
- Book ID
- 108886567
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 154 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1352-0504
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The IL28B genotype is the most important pretreatment predictor of treatment outcome in patients with chronic hepatitis C. The impact of the rs12979860 genotype on relapse was retrospectively evaluated in genotype 1/4 patients who received response-guided therapy with peginterferon alpha-2a 180 μg/w
## Abstract A study was carried out to determine whether early viral dynamics retain prediction of the outcome of peginterferon (PEG‐IFN) and ribavirin combination therapy based on different genetic polymorphisms near the __IL28B__ gene, the strongest baseline predictor of response to this therapy.
## Abstract An investigation was carried out to determine whether early viral monitoring could predict efficiently the virological response to combination therapy of two different regimens in treatment‐naïve chronic hepatitis C patients infected with genotype 1b with high baseline viral load. Patie