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IL–1β-stimulated activation of ERK1/2 and p38α MAPK mediates the transcriptional up-regulation of IL–6, IL–8 and GRO-α in HeLa cells

✍ Scribed by Huei-Ting Yang; Philip Cohen; Simon Rousseau


Book ID
113528145
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
569 KB
Volume
20
Category
Article
ISSN
0898-6568

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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL‐8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in