IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS
✍ Scribed by PENG, JUDY C; ABU BAKAR, SAZALY; RICHARDSON, MICHELLE M; JONSSON, JULIE J; FRAZER, IAN H; NIELSEN, LARS K; MORAHAN, GRANT; THOMAS, RANJENY
- Book ID
- 108944564
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 197 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0818-9641
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The production of IL-12 by dendritic cells (DC) early in an immune response is considered critical for the polarization of CD4 + T lymphocyte response towards a Th1 pattern, a key process in the clearance of intracellular pathogens. Infection of bone marrow-derived DC with Mycobacterium bovis Bacill
## Abstract IL‐12, the critical factor for the generation of the Th1 type immune response, is produced by dendritic cells (DC) upon stimulation with LPS. Different signal pathways mediate LPS‐induced expression of IL‐12 and involve PI3K, MAPK and the transcription factor NF‐κB. Here, we show that t
The protein kinase C (PKC) family is involved in the regulation of many intracellular signalling pathways. Here, we report that the PKCd isoform regulates IL-12p40/p70 production in macrophages and DC and that PKCd deficiency in mice transforms the 129/Sv healer to a non-healer strain during cutaneo