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IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases

✍ Scribed by Eva Rajnavolgyi; Naima Benbernou; Bence Rethi; Della Reynolds; Howard A. Young; Maria Magocsi; Kathrin Muegge; Scott K. Durum


Book ID
114283707
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
394 KB
Volume
14
Category
Article
ISSN
0898-6568

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Recently identified c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase are activated by stimuli of various cellular stresses, cytokines, and growth factors. Strong activation of JNK was reported in the regenerating liver, implicating JNK in growth stimulation of hepatocytes. Howe