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IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis

✍ Scribed by Carrette, Florent; Surh, Charles D.

Book ID
120043417
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
656 KB
Volume
24
Category
Article
ISSN
1044-5323

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## Abstract Interleukin‐7‐receptor‐signaling plays a pivotal role in T‐cell development and maintenance of T‐cell memory. We studied IL‐7RΞ± (CD127) expression in PBMCs obtained from patients with breast cancer and examined IL‐7 receptor‐mediated downstream effects defined by STAT5 phosphorylation (