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IL-6 and APPs: anti-inflammatory and immunosuppressive mediators

✍ Scribed by Herbert Tilg; Charles A. Dinarello; James W. Mier

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
607 KB
Volume
18
Category
Article
ISSN
0167-5699

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✦ Synopsis

Acute inflammation is accompanied by changes in the concentrations of acute phase proteins (APPs). While much is known about the cytokines involved in the initiation of inflammation, less is known about the mediators involved in its resolution. Recent data suggest that interleukin 6 (IL-6) and IL-6-regulated APPs are anti-inflammatory and immuno-suppressive, and may negatively regulate the acute phase response.

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