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IL-4 Upregulates FceRI-Mediated TSLP Expression by Human Mast Cells

✍ Scribed by Okayama, Y.; Sagara, H.; Okumura, S.; Yuki, K.; Fukuda, T.; Saito, H.

Book ID: 119278533
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 65 KB
Volume: 119
Category: Article
ISSN: 1097-6825
DOI: 10.1016/j.jaci.2006.11.571

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## Abstract Mucus hypersecretion is an important characteristic feature of the pathogenesis of allergy. Although interleukin (IL)‐4 is known to be an inflammatory mediator in respiratory diseases, the mechanism by which IL‐4 induces __MUC5AC__ gene expression has not been fully explored. The aim of