Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) occurring in the gut of genetically susceptible individuals independent of a specific pathogen. The interaction between antigen-presenting cells and the local bacterial flora contributes to an uncontrolle
✦ LIBER ✦
IL-4 signaling mechanisms in inflammatory bowel disease mononuclear phagocytes
✍ Scribed by Yvonne Rückert; Ulrike Schindler; Thomas Heinig; Susanna Nikolaus; Andreas Raedler; Dr. Stefan Schreiber
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 961 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1078-0998
No coin nor oath required. For personal study only.
✦ Synopsis
In inflammatory bowel disease (IBD), intestinal mononuclear cells secrete increased amounts of proinflammatory cytokines interleukin-1 p (IL-1 p), tumor necrosis factor-a
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We used quantitative PCR to investigate the expression of chemokines and chemokine receptors in two Th1-mediated murine models of inflammatory bowel disease (IBD). First, mRNA levels encoding the chemokines MIG, RANTES, lymphotactin, MIP-3 § , TCA-3, TARC, MIP-3 g , LIX, MCP-1 and MIP-1 g and the re