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IL-4-mediated fine tuning of IL-12p70 production by human DC

✍ Scribed by Emmanuella Guenova; Thomas Volz; Karin Sauer; Susanne Kaesler; Martin R. Müller; Florian Wölbing; KoMing Chen; Christoph Schwärzler; Peter Brossart; Martin Röcken; Tilo Biedermann


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
711 KB
Volume
38
Category
Article
ISSN
0014-2980

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IL-4 specifically induced IgE production by peripheral blood lymphocytes or by tonsil or spleen cells from healthy donors. IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-y, IFN-a, and prostaglandin E-2 (PGE-2). These substances also inhibited IL4-induce