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IL-4 and IgE–anti-IgE modulation of 15(S)-hydroxyeicosatetraenoic acid release by mononuclear phagocytes

✍ Scribed by Profita, Mirella; Vignola, Antonio M.; Mirabella, Angela; Siena, Liboria; Sala, Angelo; Gjomarkaj, Mark; Bousquet, Jean; Bonsignore, Giovanni


Book ID
119497535
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
116 KB
Volume
103
Category
Article
ISSN
1097-6825

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IL-4 specifically induced IgE production by peripheral blood lymphocytes or by tonsil or spleen cells from healthy donors. IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-y, IFN-a, and prostaglandin E-2 (PGE-2). These substances also inhibited IL4-induce