An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeri
IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells
β Scribed by Stefan Pflanz; Jackie C Timans; Jeanne Cheung; Rency Rosales; Holger Kanzler; Jonathan Gilbert; Linda Hibbert; Tatyana Churakova; Marilyn Travis; Elena Vaisberg; Wendy M Blumenschein; Jeanine D Mattson; Janet L Wagner; Wayne To; Sandra Zurawski; Terrill K McClanahan; Daniel M Gorman; J.Fernando Bazan; Rene de Waal Malefyt; Donna Rennick; Robert A Kastelein
- Book ID
- 117723234
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 529 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1074-7613
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## Abstract The basis of the adjuvant effect of ILβ1 on the clonal expansion of Agβspecific CD4 T cells was measured __in vivo__ using the TCR transgenic T cell adoptive transfer method. Injection ofAg plus ILβ1 caused naive CD4 T cells to proliferate to a greater extent than did injection of Ag al