Background: Interleukin (IL)-17F, produced in IL-23R-expressing Th17 cells, is a novel member of the IL-17 cytokine family. Given the association of IL23R with inflammatory bowel disease (IBD), we characterized the role of IL-17F in IBD including its intestinal gene expression and the effect of the
Il-22: A two-headed cytokine in IBD?
β Scribed by Julia Seiderer; Stephan Brand
- Book ID
- 102267571
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 54 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1078-0998
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## Abstract T cells exercise their full impact on target cells through a combination of secreted cytokines. The recently described T helper cell subset Th22 is characterized by a combinatorial secretion of ILβ22 and TNFβΞ±. Here, we demonstrate that ILβ22 increases the TNFβΞ±βdependent induction and