IL-2 gene C/T polymorphism is associated with prostate cancer

✍ Scribed by Hsi-Chin Wu; Chao-Hsiang Chang; Lei Wan; Chao-I Wu; Fuu-Jen Tsai; Wen-Chi Chen

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 121 KB
• Volume: 20
• Category: Article
• ISSN: 0887-8013
• DOI: 10.1002/jcla.20149

✦ Synopsis

Cytokines are reported to be associated with the formation of prostate cancer. Our aim was to investigate whether C/T polymorphisms of the interleukin-2 (IL-2) gene and IL-2 receptor beta (IL-2RB) gene are associated with prostate cancer. We compared the frequency of the polymorphisms of the IL-2 gene and the IL-2RB gene between 96 patients with prostate cancer and 105 healthy male volunteers from the same area (age >60 years). They were followed for at least 5 years. There was a significant difference in distribution of the genotype of the IL-2 gene polymorphism between the prostate cancer group and the control group (P = 0.017). The distribution of the TT homozygote of the IL-2 gene was significantly higher in the cancer group (32.3%) than in the control group (16.2%). However, no significant statistical difference was found between the polymorphism of the IL-2 gene and prostate cancer in survival analysis during a 5-year follow up period (log rank test; P = 0.19). There was no significant difference in the distribution of the genotype of the IL-2RB gene polymorphism between controls and cancer patients (P = 0.388). This study suggests that the IL-2 gene may be associated with susceptibility to prostate cancer in the Taiwan population.