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IL-1β induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat

✍ Scribed by Lisa C Parker; David A Rushforth; Nancy J Rothwell; Giamal N Luheshi


Book ID
117385503
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
156 KB
Volume
79
Category
Article
ISSN
0169-328X

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## Abstract Interleukin‐1 (IL‐1) is a key pro‐inflammatory cytokine that has diverse actions in the brain as a regulator of host defense responses and a mediator of inflammation. Two major agonists, IL‐1α and IL‐1β, bind to a single known functional type‐1 IL‐1 receptor (IL‐1RI) that associates wit