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IL-17A inhibits osteoclast development by inducing the release of GM-CSF in osteoblast lineage cells

✍ Scribed by D. Balani⁎; S. Dolder; D. Aeberli; R. Kamgang; W. Hofstetter; M. Seitz

Book ID: 116325366
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 83 KB
Volume: 50
Category: Article
ISSN: 8756-3282
DOI: 10.1016/j.bone.2012.02.260

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## Abstract IL‐17 is a proinflammatory cytokine crucial for osteoclastic bone resorption in the presence of osteoblasts or synoviocytes in rheumatoid arthritis. However, the role of IL‐17 in osteoclastogenesis from human monocytes alone remains unclear. Here, we investigated the role of IL‐17 in os