IL-12/IFN-γ/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis

1,25 dihydroxyvitamin-D3 modulates JAK–S

1,25 dihydroxyvitamin-D3 modulates JAK–STAT pathway in IL-12/IFNγ axis leading to Th1 response in experimental allergic encephalomyelitis

✍ Gladson Muthian; Himanshu P. Raikwar; Johnson Rajasingh; John J. Bright 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 423 KB

## Abstract Experimental allergic encephalomyelitis (EAE) is a Th1 cell‐mediated autoimmune disease model of multiple sclerosis (MS). Vitamin D deficiency is commonly observed in MS patients and vitamin D supplements reduce the clinical symptoms of EAE and MS. Earlier studies have shown that in viv